01PEPTIDE
Retatrutide
GLP-1 / GIP / Glucagon triple agonist for substantial weight loss and metabolic improvement.
Weight ManagementAppetiteGlucose / Insulin
EXPLORE THIS GOAL · MW
Metabolic + Weight
Appetite, glucose signaling and body composition. Use this dashboard to move between records, protocols, comparisons, research and tools.
01
Relevant peptides
02PEPTIDE
Tirzepatide
Dual GIP / GLP-1 receptor agonist for superior weight loss and glycemic control.
Weight ManagementAppetiteGlucose / Insulin
03PEPTIDE
Semaglutide
Long-acting selective GLP-1 receptor agonist for weight loss and glycemic control.
Weight ManagementAppetiteGlucose / Insulin
04PEPTIDE
Cagrilintide + Semaglutide (CagriSema)
Fixed dual combination of long-acting amylin analog + GLP-1 agonist for enhanced weight loss.
Weight ManagementAppetiteGlucose / Insulin
05PEPTIDE
Survodutide
An investigational GLP-1 and glucagon receptor dual agonist in clinical development for obesity and metabolic liver disease.
Weight ManagementAppetiteFat Loss
06PEPTIDE
Cagrilintide
Long-acting amylin analog for appetite regulation and weight management (often studied with semaglutide as CagriSema).
Weight ManagementAppetiteFat Loss
07PEPTIDE
Mazdutide
A GLP-1 and glucagon receptor dual agonist studied in obesity and type 2 diabetes, with development and regulatory status varying by region.
Weight ManagementGlucose / InsulinFat Loss
08PEPTIDE
Pemvidutide
An investigational GLP-1 and glucagon receptor dual agonist studied for obesity and metabolic liver disease.
Weight ManagementFat LossBody Composition
09PEPTIDE
Liraglutide
An approved daily GLP-1 receptor agonist studied for type 2 diabetes, weight management and cardiovascular outcomes.
Weight ManagementAppetiteGlucose / Insulin
10PEPTIDE
AOD 9604
Modified hGH fragment (176-191) studied for lipolysis without significant IGF-1 elevation.
Fat LossWeight ManagementBody Composition
11PEPTIDE
Tesamorelin
Synthetic GHRH analog that stimulates endogenous GH release for visceral fat reduction.
Body CompositionFat LossNeuroendocrine
12PEPTIDE
5-Amino-1MQ
A small-molecule NNMT inhibitor studied primarily in preclinical metabolic and adipose-tissue models.
Fat LossBody CompositionMetabolic
13PEPTIDE
Ipamorelin
Selective growth hormone secretagogue (GHRP) with minimal effect on cortisol or prolactin.
NeuroendocrineBody CompositionRecovery
14PEPTIDE
CJC-1295 (with DAC)
Long-acting GHRH analog that provides sustained GH and IGF-1 elevation for several days.
NeuroendocrineBody CompositionRecovery
15PEPTIDE
Sermorelin
Short-acting GHRH analog that amplifies the body’s natural growth-hormone pulses.
NeuroendocrineBody CompositionRecovery
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Related protocols
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Popular comparisons
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Related research
SPONSOR UPDATETRIUMPH-1 Phase 3 topline resultsRetatrutide · Eli Lilly and Company · 2026SPONSOR UPDATETRIUMPH-2 and TRIUMPH-3 Phase 3 topline results and planned regulatory submissionRetatrutide · Eli Lilly and Company · 2026REGULATORYWhat to know about retatrutideRetatrutide · Eli Lilly and Company · 2026CLINICAL TRIALCoadministered Cagrilintide and Semaglutide in Adults with Overweight or ObesityCagrilintide + Semaglutide (CagriSema) · New England Journal of Medicine · 2025CLINICAL TRIALTriple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver diseaseRetatrutide · Nature Medicine · 2024CLINICAL TRIALGlucagon and GLP-1 receptor dual agonist survodutide for obesitySurvodutide · The Lancet Diabetes & Endocrinology · 2024
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Tools
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Related goals
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