LongevityHealthy AgingCellular RepairLongevity / telomere and pineal supportCircadian and melatonin regulation

RESEARCH REFERENCE

Epitalon (Epithalon)

Synthetic tetrapeptide (Ala-Glu-Asp-Gly) researched for pineal regulation, telomere support, and longevity signaling.

Quick Reference

Dose: 5–10 mg per day
Frequency / schedule: Daily during short course
Route: Subcutaneous
Timing: Evening preferred (or morning in some protocols)
Fasting: Flexible (evening dosing does not require fasting)
Cycle: 10–20 consecutive days per course
Time off: 3–6 months between courses (1–2 courses per year typical)
Common vial strengths: 10 mg, 50 mg

How this works

Epitalon is a synthetic version of the active component of the pineal peptide preparation Epithalamin developed by the Khavinson group. It is studied for effects on telomerase activity, telomere length maintenance, normalization of melatonin secretion, and regulation of circadian rhythms. Protocols are short pulsed courses rather than continuous daily use, based on the idea that it triggers longer-lasting regulatory cascades.

Benefits + side effects

Potential Benefits

Potential telomere and cellular longevity support (preclinical + Russian research)
Improved circadian / melatonin regulation in older subjects (older human data)

Side Effects

Generally well tolerated in reported use
Limited modern controlled human safety data

Dosing / Protocol

Reference Protocol

Phase / week	Dose	Frequency	Timing	Notes
Standard high	10 mg	10 days	1–2× per year	Most cited Russian-style
Standard spread	5 mg	20 days	1–2× per year	Same total dose, longer window
Conservative	5 mg	10–20 days	1–2× per year	Lower daily exposure

Timing + Fasting Notes

Evening dosing (30–60 min before bed) is most common to align with pineal / melatonin rhythms. Some protocols use morning. Food does not appear to significantly affect it.

Reconstitution

Common vial strengths10 mg, 50 mg

Approved preparation example
10 mg + 1–2 mL BAC water (adjust for easy units)

Practical Reference

Storage: Lyophilized frozen/refrigerated; reconstituted refrigerated
Route / injection context: Subcutaneous
Bloodwork / markers: Subjective sleep/circadian tracking; telomere testing if available (research context)
Common vial strengths: 10 mg, 50 mg
Cycle / time off: 10–20 consecutive days per course · 3–6 months between courses (1–2 courses per year typical)
Practical notes: Short pulsed courses only — not meant for continuous daily use year-round. Research use only.

References

Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activityBiogerontology · 2025

PRECLINICAL

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