Oxidative StressPigmentationCellular RepairSkin QualityAntioxidant / detox support

RESEARCH REFERENCE

Glutathione

Master intracellular antioxidant (often supported by NAC).

Quick Reference

Dose: Oral GSH 500–1000 mg + NAC 600–1800 mg; injectable 200–1200 mg
Frequency / schedule: Daily oral or 2–3× weekly injectable
Route: Oral (liposomal preferred) or SC/IM
Timing: Morning preferred
Fasting: Empty stomach preferred for better absorption
Cycle: Ongoing or 8–12 weeks
Time off: Optional breaks
Common vial strengths: Injectable 600–1200 mg

How this works

Glutathione neutralizes reactive oxygen species and supports Phase II detoxification. NAC supplies the rate-limiting precursor (cysteine) to raise endogenous glutathione levels more reliably than oral glutathione alone.

Benefits + side effects

Potential Benefits

Reduced oxidative stress
Liver enzyme support in clinical contexts

Side Effects

Excellent safety; mild GI with oral NAC possible

Dosing / Protocol

Reference Protocol

Phase / week	Dose	Frequency	Timing	Notes
Oral	NAC 600–1200 mg + GSH 500 mg	Daily	Morning, empty	Most practical
Injectable	200–600 mg	2–3× weekly	Flexible	Higher bioavailability

Timing + Fasting Notes

Morning on an empty stomach is preferred for oral forms.

Practical Reference

Storage: Per form
Route / injection context: Oral (liposomal preferred) or SC/IM
Common vial strengths: Injectable 600–1200 mg
Cycle / time off: Ongoing or 8–12 weeks · Optional breaks
Practical notes: NAC is often more effective than oral GSH alone for raising levels. Research / supplemental use.

References

Randomized controlled trial of oral glutathione supplementation on body stores of glutathioneEuropean Journal of Nutrition · 2015 · DOI 10.1007/s00394-014-0706-z

HUMAN02

Effects of oral glutathione supplementation on systemic oxidative stress biomarkers in human volunteersJournal of Alternative and Complementary Medicine · 2011

HUMAN03

Glutathione as an oral whitening agent: a randomized, double-blind, placebo-controlled studyJournal of Dermatological Treatment · 2012

HUMAN04

Oral Glutathione and Growth in Cystic Fibrosis: A Multicenter, Randomized, Placebo-controlled, Double-blind TrialJournal of Pediatric Gastroenterology and Nutrition · 2020 · DOI 10.1097/MPG.0000000000002948

HUMAN

THE SIGNAL · SENT TWICE A MONTH

Stay ahead of the research without living on PubMed.

Peptide references, research worth knowing, new FEMETRIC tools, and meaningful testing updates. Twice a month. No daily emails.By subscribing, you agree to receive The Signal from FEMETRIC. Unsubscribe anytime.

Search Femetric