Reproductive SignalingNeuroendocrineLibidoSexual WellnessReproductive hormone axis / libido research

RESEARCH REFERENCE

Kisspeptin-10

Neuropeptide that stimulates GnRH release → LH/FSH for reproductive axis support.

Quick Reference

Dose: 50–200 mcg
Frequency / schedule: Pulsed (every other day or short cycles)
Route: Subcutaneous
Timing: Flexible
Fasting: Not required
Cycle: 2–6 weeks short cycles
Time off: Essential to avoid tachyphylaxis

How this works

Activates the Kiss1 receptor in the hypothalamus, triggering GnRH pulses that then stimulate LH and FSH release from the pituitary.

Benefits + side effects

Potential Benefits

Stimulates natural gonadotropin release
Research interest in sexual function and fertility

Side Effects

Flushing, mild headache, nausea
Desensitization with continuous daily use

Dosing / Protocol

Reference Protocol

Phase / week	Dose	Frequency	Timing	Notes
Standard	100–200 mcg	Every other day	Flexible	Avoid continuous daily

Timing + Fasting Notes

Flexible. Food does not matter.

Practical Reference

Storage: Refrigerated reconstituted
Route / injection context: Subcutaneous
Cycle / time off: 2–6 weeks short cycles · Essential to avoid tachyphylaxis
Practical notes: Pulsed dosing is critical. Research use only.

References

Effects of Kisspeptin Administration in Women With Hypoactive Sexual Desire DisorderJAMA Network Open · 2022

CLINICAL TRIAL

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