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Mitochondrial HealthEnergyMetabolicEnduranceHealthy Aging

Mitochondrial-derived peptide

MOTS-C

MOTS-C is encoded within mitochondrial DNA and has been investigated as a signaling molecule connecting cellular stress, metabolism and exercise adaptation.

FEMETRIC RECORD · PUBLICMOTS-C
Mitochondrial HealthEnergyMetabolic
Status
Preclinical / Research
Related
3
Sources
4
UPDATED 2026-09-09
01

Protocol references

PENDING VERIFICATION

PLACEHOLDER / UNVERIFIED

Research planning sample

Administration fields remain pending human interventional evidence review.

Route
Subcutaneous research
Frequency
3× weekly
Duration
4 weeks
Escalation
Not established
STAGEWEEKSSTUDY DOSE
11525 mg · 3×/wk
PLACEHOLDER / UNVERIFIEDFemetric planning field under editorial reviewVerified 2026-09-09
03

Supply / calculator inputs

01 · STUDY SOURCEResearch planning sampleFemetric planning field under editorial reviewPENDING VERIFICATION
02 · PREPARATION INPUT10 mg planning vialFemetric planning inputPENDING VERIFICATION
03 · DERIVED ESTIMATE6 vials60 mg across 4 weeks
60 mgPeptide total
6Research vials
12 mLBAC water
12Administrations

Study dose data and preparation inputs are separate records. Changing vial or liquid settings does not change the published study arm.

04

How this works

MOTS-c is a mitochondrial-derived peptide studied in metabolic homeostasis, cellular stress and exercise biology. Human studies currently include endogenous expression and association data; administered-use evidence remains largely preclinical.

Mechanism summaries are stored with field-level source provenance for editorial audit.
07

Related research goals

08

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02PEPTIDE

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03PEPTIDE

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09

Compare MOTS-C

REVIEW

Related Research Reviews

COMMERCIAL DISPLAY · PENDING REVIEW

Vendor architecture is retained, but commerce is not displayed until product and policy review are complete.

11

References

01
The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistanceCell Metabolism · 2015
PRECLINICAL
02
MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolismFree Radical Biology and Medicine · 2016
REVIEW
03
The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivityPhysiological Reports · 2019 · DOI 10.14814/phy2.14171
PRECLINICAL
04
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasisNature Communications · 2021
HUMAN
Page reviewed: 2026-09-09References updated: 2026-09-09

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