Cognitive / FocusCellular RepairNeuroendocrineFocus, memory, and cognitive performanceNeuroprotection

RESEARCH REFERENCE

Semax

Synthetic ACTH(4-10) analog for cognitive enhancement and neuroprotection.

Quick Reference

Dose: 200–600 mcg
Frequency / schedule: 1–3× daily
Route: Intranasal preferred; subcutaneous possible
Timing: Morning / daytime
Fasting: Not required
Cycle: Days to several weeks
Time off: Common after courses
Common vial strengths: Research 5–10 mg; nasal solutions available

How this works

Semax upregulates BDNF and NGF, modulates dopaminergic and serotonergic transmission, and supports neuroplasticity without corticotropic (adrenal-stimulating) activity.

Benefits + side effects

Potential Benefits

Improved focus and cognitive function
Neuroprotective effects (Russian clinical data)

Side Effects

Mild nasal irritation (intranasal)
Generally excellent tolerability

Dosing / Protocol

Reference Protocol

Phase / week	Dose	Frequency	Timing	Notes
Cognitive	200–600 mcg	2–3× daily	Daytime	Standard nootropic

Timing + Fasting Notes

Daytime dosing. Food does not matter.

Practical Reference

Storage: Refrigerated
Route / injection context: Intranasal preferred; subcutaneous possible
Common vial strengths: Research 5–10 mg; nasal solutions available
Cycle / time off: Days to several weeks · Common after courses
Practical notes: N-Acetyl versions have improved stability. Research use only.

References

Semax, an ACTH4-10 peptide analogue with nootropic propertiesNeuroscience and Behavioral Physiology · 2006

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