01 · FEMETRIC REFERENCE
Reconstitution Guide
Concentration, draw volume and U-100 markings with the three inputs kept visibly separate.VIAL AMOUNT10 mg
/FINAL VOLUME2 mL
=CONCENTRATION5 mg/mL
thenTARGET AMOUNT0.25 mg
/CONCENTRATION5 mg/mL
=DRAW0.05 mL / 5 units
The three-step relationship
Concentration equals vial amount divided by final liquid volume. Draw volume equals target amount divided by concentration. On a U-100 syringe, volume in milliliters multiplied by 100 gives the barrel marking.
Worked example
If a vial contains 10 mg in a final volume of 2 mL, the concentration is 5 mg/mL. A 0.25 mg target corresponds to 0.05 mL, which is the 5-unit mark on a U-100 syringe.
| Known input | Value | Operation |
|---|---|---|
| Vial amount | 10 mg | 10 mg / 2 mL |
| Concentration | 5 mg/mL | 0.25 mg / 5 mg/mL |
| Draw volume | 0.05 mL | 0.05 mL x 100 |
| U-100 marking | 5 units | Calculated volume marking |
What the calculator cannot verify
Arithmetic cannot establish sterility, product identity, formulation compatibility, stability or an appropriate target amount. Product labeling and qualified clinical instruction control.
Primary and authoritative context
U.S. CDCPreventing unsafe injection practicesNEXT RESEARCH ACTION